Type 2 diabetics may find heart benefits with resveratrol
Protecting the Powerhouse
Why resveratrol?
This compound, a component of red wine, has been shown to provide important health benefits, including:
* Anti-inflammatory effects
* Inhibition of blood clotting
* Help in prevention of LDL cholesterol from depositing arterial plaque
* Stimulation of an enzyme that promotes repair of DNA
* Protection of heart and nerve cells
2008 research from the UK reveals another potential benefit for type 2 diabetics.
Leaky cells
High levels of glucose cause cellular damage to the blood vessels of type 2 diabetics. Specifically, the powerhouses of the cells – the mitochondria – become weakened, setting off a reaction that produces free radical activity. Studies show that regular exercise is the ideal way to stimulate and repair mitochondria. And along with a daily exercise regimen, a little resveratrol might help.
In a laboratory study conducted at the Peninsula Medical School in the UK, researchers found that resveratrol produced enzymes that protected and restored glucose-damaged bovine aortic endothelial cells by preventing a “leakage” of electrons from the mitochondria. That electron leakage is what sets off the damaging free radicals.
In a press release, Peninsula lead investigator Dr. Matt Whiteman noted that resveratrol might be useful in helping prevent certain life-threatening complications associated with type 2 diabetes. Dr. Whiteman: “It could well be the basis of effective diet-based therapies for the prevention of vascular damage caused by hyperglycaemia in the future.”
From Oprah to Oz
You may have noticed there’s no shortage of resveratrol supplements on the market these days. But according to a recent New York Times article, buyers must be wary of resveratrol supplements that appear to be endorsed by celebrities.
Some web sites that sell these supplements carry endorsements from Barbara Walters, Oprah Winfrey, Dr. Mehmet Oz, and the researcher who discovered resveratrol’s anti-aging benefits, Dr. David Sinclair.
One problem: None of these people have ever endorsed a resveratrol product. So when considering a resveratrol supplement, talk to your doctor first, then take extra care in ensuring that the source is reputable.
In addition to red wine, resveratrol can be found in red grape skins, peanuts, and some berries. Red grapes also contain anthocyanins – antioxidants that protect arteries and microcapillaries – a key benefit for patients with circulation-related health problems such as diabetic retinopathy, macular degeneration, cataracts, glaucoma, and varicose veins.
Although red wine is a good source of resveratrol, alcohol should always be taken in moderation.
Sources:
“Resveratrol Blocks High Glucose-Induced Mitochondrial Reactive Oxygen Species Production in Bovine Aortic Endothelial Cells: Role of Phase 2 Enzyme Induction?” Diabetes, Obesity and Metabolism, Vol. 10, No. 4, April 2008, blackwell-synergy.com
“Grape Skin Compound Fights the Complications of Diabetes” Press release from The Peninsula College of Medicine and Dentistry, 3/14/08, eurekalert.org
“With Resveratrol, Buyer Beware” Sarah Arnquist, New York Times, 8/18/09, nytimes.com
