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Folate reduces the risk of high blood pressure

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High blood pressure isn’t a disease, in the same way that a high fever isn’t a disease – it’s a sign that something else is wrong. If you and your doctor discover and address the root problem of hypertension, you’re more likely to successfully treat it.

Obviously, blood pressure is closely tied to the health of your heart, so it’s no surprise really to find a new study that demonstrates how the intake of a key nutrient that promotes heart health may also alleviate hypertension risk.

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Nursing the heart
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In a January issue of the Journal of the American Medical Association, researchers at Harvard Medical School report on a study that examines the association between hypertension risk and the intake of folate; a B vitamin.

Researchers collected data from two phases of the Nurses’ Health Study. The first phase examined eight years of medical and dietary records for well over 93,000 women under the age of 44. The second phase included the records of more than 62,000 women, aged 43 to 70. None of the women
in either phase had been diagnosed with hypertension at the outset of the study.

When the Harvard team compared medical records to information about folate intake from regularly updated dietary questionnaires, they found a general correlation between a high intake of folate and reduced risk of high blood pressure.

More specifically, among women in the younger group who consumed a minimum of 1 mg of folate daily, hypertension risk was decreased by more than 45 percent, compared to women who consumed less than 0.2 mg every day. In the group of older women, risk was cut by nearly 20 percent when
folate intake was at least 1 mg. Folate intake included both dietary and supplemental sources.

Here are some foods that contain high folate concentrations:

Chicken Liver: 3.5 oz. contains 770 micrograms (mcg)
Braised Beef Liver: 3.5 oz. contains 217 mcg
Lentils: 1/2 cup (cooked) contains 180 mcg
Asparagus: 1/2 cup contains 132 mcg
Spinach: 1/2 cup (cooked) contains 131 mcg
Kidney Beans: 1/2 cup contains 115 mcg
Orange: one medium orange contains 47 mcg.

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Folate therapy
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Studies show that hypertension patients often have high levels of homocysteine – the amino acid that promotes plaque buildup on blood vessel walls.

As I’ve noted in previous e-Alerts, folate is a key nutrient for heart health because it reduces homocysteine – especially when taken with vitamins B-6 and B-12; a combination sometimes referred to as “folate therapy.” The idea behind the therapy is simple: This set of nutrients promotes the efficient metabolism of homocysteine, which brings the
level down.

In the e-Alert “The B List” (2/2/04), HSI Panelist Allan Spreen, M.D., told us that low doses of folic acid (the synthetic form of folate) aren’t effective except in a small percentage of cases. He recommends 1.6 mg per day, although he believes that a dosage closer to 5 mg is better for those who want to address cardiovascular problems.

Unfortunately, folic acid is only available in very low doses of 0.8 mg (800 mcg), as mandated by the FDA. Dr. Spreen explains: “That’s all from the conventional medical dogma that folate can mask a vitamin B-12 deficiency if you take too much folate and zero B-12.” So take more B-12. Problem solved!

Dr. Spreen recommends 1 mg of B-12 per day in sublingual form. To complete the folate therapy combination, he also recommends 100 mg per day of B-6, and 400-500 mg of magnesium per day to make the B-6 more effective.

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and another thing

Prostate cancer is a paradox. On one hand, it can be a deadly form of cancer, but on the other hand it’s not very aggressive. In fact, it’s such a slow-growing disease that many older men who are diagnosed with prostate cancer will probably die of other causes, even if their cancer goes untreated.

This paradox is illustrated by the results of a recent study reported in the New England Journal of Medicine.

Researchers at the University of Texas Medical Branch analyzed six years of medical records for more than 50,000 men who were diagnosed with prostate cancer. The Texas team found that androgen-deprivation therapy (a common prostate cancer treatment that suppresses testosterone
production) significantly increases the risk of bone fracture.

The problem here is that broken bones present a serious health challenge for the elderly. Infections that heal slowly and other problems associated with bone fractures can set off a chain of events that often result in premature death. So for an older man who’s diagnosed with an early stage of prostate cancer, the “cure” may be far more dangerous than the slow-growing disease.

Other adverse side effects linked to androgen-deprivation therapy include loss of muscle mass, reduced mental sharpness and hot flashes.

To Your Good Health,

Jenny Thompson
Health Sciences Institute

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“Heart Health Alert: Don’t listen to your doctor!”

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Sources:

“Folate Intake and the Risk of Incident Hypertension Among U.S. Women”
Journal of the American Medical Association, Vol. 293, No. 3, 1/19/05, jama.ama-assn.org


“Folic Acid ‘Cuts Blood Pressure'” BBC News, 1/19/05, news.bbc.co.uk

“Risk of Fracture After Androgen Deprivation for Prostate Cancer” The New England Journal of Medicine, Vol. 352, No. 2, 1/13/05,content.nejm.org

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