Natural green cure hits a deadly target Big Pharma can’t touch
There’s a dangerous enzyme linked with many chronic and deadly diseases, from cancer to Alzheimer’s disease.
Big Pharma has identified this enzyme as a promising drug target1. And corporate researchers are in a desperate race to come up with the first drug to impact that enzyme.
So far, they’ve got nothing.
But there is already something that works to shut down the deadly enzyme, something natural. And, so far, no drug company has been able to match its curative powers.
Can this enzyme be stopped?
P21-activated kinases, known as PAKs, are a family of enzymes, some of which play critical roles in disease development… as researchers learned decades ago.
And one of the most studied, most activating is PAK1, found to be responsible for numerous debilitation conditions:
- cancer, especially solid tumors2,3
- Alzheimer’s disease4
- inflammatory bowel disease5
- asthma6
- heart failure7
- arthritis6
- autism6
- neurofibromatosis6 (a severe brain tumor disease)
- cardiovascular disease8
- inflammatory diseases8
So you can see why drug companies would be tripping over themselves trying to create a drug that controls PAK1… but 20 years later, and they still have nothing.
PAK1 fuels cancer
One thing we know for sure: too much PAK activity fuels cancer development.
When PAK1 works overtime, it enables many of the cell activities that define cancer, like invasion and spread.9,10 Brain tumors brought on by neurofibromatosis actually require PAK1 to grow. In fact, more than 70% of cancers—including glioma, breast, and pancreatic cancers—depend on PAK1 for survival.11
So it makes sense that a PAK1 stopper could halt cancer in its tracks… and it does, but that stopper didn’t come from a corporate test tube.
It came from Nature. And drug company researchers—even U.S. government researchers—know it.
Researchers hide cancer cure?!
Back in May 2013, HSI uncovered a shocking government email chain (you can find the full exposé in the HSI archives at hsionline.com) in which researchers were openly discussing treatments for a known PAK1-related deadly cancer, neurofibromasis, and this is what they said about it:
“…propolis is the only effective therapeutic available on the market so far.” (I added the bold.)
But that information is yet to be released to the general public—an effective therapy for a deadly cancer that government scientists know about—and there’s only one imaginable explanation: They haven’t figured out how to turn it into a money-making drug yet.
And while government and corporate researchers alike race to create a copycat drug that will have to go through years of testing—and still may not work as effectively—you have access to the original disease-fighting compound right now, today.
Brazilian bees create what the drug companies can’t
Bees all around the world instinctively create what years of research can’t quite figure out: anti-PAK1 compounds.
Some scientists believe that bees could be drawn to anti-PAK1 substances in plants. That would go a long way toward explaining how bees everywhere—New Zealand, Wisconsin, Brazil—make very chemically different propolis, yet virtually all propolis seems to target PAK1.
And certain propolis, specifically Brazilian green propolis, has a uniquely powerful anti-PAK1 impact. You see, this propolis contains very high levels of a natural compound called artepillin-C, or ARC.
ARC has been a research target for some time now, yet we are just beginning to learn its full range of powers. And it’s just one of the disease-fighting compounds naturally found in Brazilian green propolis.
Brazilian bees foil deadly cancers
Though there aren’t yet any formal human clinical trials demonstrating propolis’ cancer-fighting abilities, scientific evidence is stacking up… especially when it comes to Brazilian green and ARC.
To start, Brazilian green propolis was found to help prevent skin cancer,12 have an anti-tumor effect on brain cells,13 and, most recently, have cancer-fighting power against certain lung cancers.14
ARC from Brazilian green propolis helps re-sensitize resistant prostate cancer cells to chemotherapy, boosting the conventional treatment’s effectiveness.15
And a robust animal study11 found that ARC from Brazilian green propolis selectively blocked PAK1—but not other necessary enzymes—in mice with neurofibromatosis tumors. Researchers also learned that one way ARC works is to stop a process called angiogenesis, where tumors create special dedicated blood vessels to deliver the nutrients they need to thrive.
Propolis cures more than cancer
Though much research involving propolis and ARC has centered on cancer, this natural wonder has been shown to impact many other conditions.
A just-published animal study16 found that propolis treatment worked better than a powerful steroid for functional recovery after sciatic nerve crush injuries. Another study17 found that propolis worked as well as a powerful NSAID, diclofenac, to reduce inflammation in an animal model of arthritis.
Brazilian green propolis was specifically studied and found to protect against brain cell damage even when those brain cells were starved of glucose and oxygen18 or subject to extreme oxidative stress.19
Research has also shown that this propolis can positively impact
- depression20
- viruses21
- inflammation22, 23,24
- age-related macular degeneration25
- periodontal disease26
- influenza27
- diabetes28,29,30
In fact, a clinical trial31 published in May 2015 found that Brazilian green propolis could help ward off some of the effects of type 2 diabetes. This randomized double blind, placebo-controlled trial included 80 diabetic patients. And during the study period, each either took Brazilian green propolis or placebo for eight weeks. The patients getting propolis had better outcomes on two key measures of diabetic health: uric acid and eGFR (glomerular filtration rate), both of which speak to kidney health.
On top of all that, Brazilian green propolis has a very positive effect on your immune system. A recent study found that this natural compound improves innate and adaptive immunity in aged mice.32 And another looked at the overwhelmingly positive immune-modulating properties of Brazilian green, leading the researchers to call for further studies.33
But you don’t have to wait for more studies or drug development to start reaping the benefits of Brazilian green propolis and its natural disease-fighting compounds.
Bees hold the key to fighting disease
Whether you want to bolster your immune system, combat cancer, or fight another disease, Brazilian green propolis holds the key.
Unlike other propolis products on the market, NaturaNectar™ Green Bee Propolis is prepared using an exclusive water based extraction process called Green Extraction™, making this propolis more potent than any other on the market.
The recommended dosage for maintaining good health is one 100 mg capsule once or twice per day. For additional support, it’s safe to take 500 mg once daily.
NaturaNectar™ Green Bee Propolis
NaturaNectar, Ph: 800-609-7794; www.naturanectar.com
Green Bee Propolis costs US$57.99 for 60 capsules. HSI members will receive exclusive savings: To get a 15% discount on one or two bottles, use code HSIGP15 when ordering. To get a 20% discount on orders of three bottles or more, use code HSIGP20 when placing your order.
Article Citations:
- Julia V Kichina, PhD, et al., PAK1 AS A THERAPEUTIC TARGET, Expert Opin Ther Targets. 2010 Jul; 14(7): 703–725.
- Dammann K1, Khare V1, Gasche C1. Republished: tracing PAKs from GI inflammation to cancer. Postgrad Med J. 2014 Nov;90(1069):657-68. doi: 10.1136/postgradmedj-2014-306768rep.
- Abdel-Magid AF1. et al., PAK1: A Therapeutic Target for Cancer Treatment. ACS Med Chem Lett. 2013 Mar 19;4(5):431-2. doi: 10.1021/ml400101g. eCollection 2013.
- Ma QL1, et al., PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist. 2012 Apr 1;2(2):117-125.
- Khare V1, et al., Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer. Inflamm Bowel Dis. 2015 Feb;21(2):287-96. doi: 10.1097/MIB.0000000000000281.
- Maruta H1. Et al., Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity. Phytother Res. 2014 May;28(5):656-72.
- Wang Y1, et al., Novel insights into mechanisms for Pak1-mediated regulation of cardiac Ca(2+) homeostasis. Front Physiol. 2015 Mar 17;6:76. doi: 10.3389/fphys.2015.00076. eCollection 2015.
- Taglieri DM1, Ushio-Fukai M2, Monasky MM3. P21-activated kinase in inflammatory and cardiovascular disease. Cell Signal. 2014 Sep;26(9):2060-9. doi: 10.1016/j.cellsig.2014.04.020. Epub 2014 May 2.
- Maria Radu, et al., PAK signalling during the development and progression of cancer. Nature Reviews Cancer 14,13–25 (2014)
- Coniglio SJ1, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol. 2008 Jun;28(12):4162-72. doi: 10.1128/MCB.01532-07. Epub 2008 Apr 14.
- Messerli SM1, et al., Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice. Phytother Res. 2009 Mar;23(3):423-7.
- GOMES, M. Z., et al., Chemopreventive effect of Brazilian green propolis on experimental dermal carcinogenesis in murine model. Int. J. Morphol., 32(2):522-530, 2014.
- Ishiai S1, et al., Histone deacetylase inhibitory effect of Brazilian propolis and its association with the antitumor effect in Neuro2a cells. Food Sci Nutr. 2014 Sep;2(5):565-70.
- Frión-Herrera Y1, Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. J Pharm Pharmacol. 2015 Jul 21. doi: 10.1111/jphp.12449. [Epub ahead of print]
- Szliszka E1, et al., Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis. Int J Oncol. 2012 Sep;41(3):818-28.
- Yüce S1, et al., An experimental comparison of the effects of propolis, curcumin, and methylprednisolone on crush injuries of the sciatic nerve. Ann Plast Surg. 2015 Jun;74(6):684-92.
- Khayyal MT1, et al., Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Exp Clin Res. 1993;19(5):197-203.
- Nakajima Y1, et al., Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytother Res. 2009 Oct;23(10):1431-8.
- Masamitsu Shimazawa,1 Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage Evid Based Complement Alternat Med. 2005 Jun; 2(2): 201–207. Published online 2005 Apr 13. doi: 1093/ecam/neh078
- Lee MS1, et al., Novel antidepressant-like activity of propolis extract mediated by enhanced glucocorticoid receptor function in the hippocampus. Evid Based Complement Alternat Med. 2013;2013:217853.
- Hayakari R1, et al., Effects of Brazilian green propolis on double-stranded RNA-mediated induction of interferon-inducible gene and inhibition of recruitment of polymorphonuclear cells. J Sci Food Agric. 2013 Feb;93(3):646-51.
- Chirumbolo S1 Anti-inflammatory property of propolis. J Clin Biochem Nutr. 2015 Mar;56(2):163-4. doi: 10.3164/jcbn.14-110. Epub 2015 Feb 7.
- Hori JI1, et al., The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evid Based Complement Alternat Med. 2013;2013:418508.
- Szliszka E1, et al., Inhibition of Inflammatory Response by Artepillin C in Activated RAW264.7 Macrophages. Evid Based Complement Alternat Med. 2013;2013:735176.
- Murase H1, et al., The Effects of Brazilian Green Propolis against Excessive Light-Induced Cell Damage in Retina and Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:238279.
- Skaba D1, et al., Influence of the toothpaste with brazilian ethanol extract propolis on the oral cavity health. Evid Based Complement Alternat Med. 2013;2013:215391.
- Shimizu T1, et al., Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother. 2008;19(1):7-13.
- Mohamed T. Al-Hariri Propolis and its direct and indirect hypoglycemic effect J Family Community Med. 2011 Sep-Dec; 18(3): 152–154.
- Kitamura H1, et al., Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue. Adipocyte. 2013 Oct 1;2(4):227-36.
- Al-Hariri M1, et al., Glycemic control and anti-osteopathic effect of propolis in diabetic rats. Diabetes Metab Syndr Obes. 2011;4:377-84.
- Fukuda T1, et al., Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomed Rep. 2015 May;3(3):355-360. Epub 2015 Feb 25.
- Gao W1, et al., Brazilian green propolis improves immune function in aged mice. J Clin Biochem Nutr. 2014 Jul;55(1):7-10.
- de Figueiredo SM, et al., Immunomodulatory properties of green propolis. Recent Pat Endocr Metab Immune Drug Discov. 2014;8(2):85-94.