Are “Forever Chemicals” Putting Your Kidneys at Risk?

By now, you have likely heard about the dangers of PFAS—often called “forever chemicals”—and how they’ve quietly slipped into everything from nonstick cookware to water-resistant clothing.

But what you might not know is that these chemicals could pose risks to your kidney health through changes in gut bacteria.

New research from the University of Southern California has uncovered how PFAS exposure may impact kidney function, particularly in younger people.

If you have children or grandchildren in their 20s or 30s, this is worth passing along, especially given the widespread exposure to these chemicals.

In this study, researchers looked at a group of young adults who were already at a higher risk for metabolic issues due to their weight.

Over four years, the team monitored their kidney health and analyzed their blood for PFAS levels and other metabolites. Stool samples were also collected to understand changes in the gut microbiome.

They found that even small increases in PFAS exposure were linked to declines in kidney function. In fact, for each increase in PFAS exposure, kidney function dropped by around 2.4%.

While this might seem minor at first glance, the kidneys are delicate, and even slight declines can set the stage for greater risks, especially as we age.

What’s particularly concerning—and fascinating—is how the gut microbiome seems to play a role in PFAS-related kidney damage. The researchers observed that the young adults with higher PFAS levels had less “good” bacteria that produce anti-inflammatory compounds, along with higher levels of inflammatory metabolites.

Imagine this as a gut imbalance that stirs up inflammation and disrupts kidney health over time. Scientists found that about 38% to 50% of the PFAS impact on kidney function could be traced back to these gut and metabolite changes.

It’s a reminder that a healthy gut doesn’t just affect digestion; it’s key for overall health, including kidney function.

While these results are eye-opening, it’s worth noting that this study was relatively small and focused on young adults with specific health factors. The research team has called for more studies with diverse groups and larger sample sizes to understand the exact pathways PFAS take to impact gut and kidney health.

Still, these findings add to growing evidence that PFAS chemicals have a harmful impact on the body and may even affect health across generations.

If you’re concerned about PFAS in your home or for your family, here are a few simple ways to limit exposure:

Filter Your Water: Consider using a water filter designed to reduce PFAS, especially in areas known for contamination.
Choose Cookware Wisely: Nonstick pans often contain PFAS. Try switching to stainless steel, cast iron, or glass options.
Check Personal Care Products: Look for “PFAS-free” labels, especially on waterproof cosmetics.
Be Mindful of Food Packaging: Some takeout containers and popcorn bags are lined with PFAS—opt for homemade or alternative packaging when possible.

This new research serves as a timely reminder that we ALL need to stay informed about what’s in our products. Whether you’re protecting your own health or looking out for the next generation, reducing exposure to PFAS is a wise step toward better health.

To staying safe—and passing on the knowledge!

Rachel Mace
Managing Editorial Director, e-Alert
with contributions from the research team

Sources:

Edited by Manasi Talwadekar. (2024, November 5). PFAS May Affect Kidneys via Gut Microbes, Blood Metabolites. Medscape. https://www.medscape.com/viewarticle/pfas-may-affect-kidneys-gut-microbes-blood-metabolites-2024a1000k6g