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Why Early Detection Is KEY in the Fight Against Pancreatic Cancer

Imagine a world where a simple blood test could tell you if you have pancreatic cancer—before any symptoms appear, and when treatment is most likely to be successful.

It might sound like science fiction, but researchers across the globe are working tirelessly to make this vision a reality.

Why the urgency?

Because pancreatic cancer is a stealthy and deadly foe. It’s rarely caught in the early stages, when surgery could potentially cure it. And by the time symptoms like abdominal pain, jaundice, and weight loss appear, the cancer has often already spread.

The statistics are sobering. Although pancreatic cancer accounts for just 3 percent of all new cancer cases in the US, it’s the third leading cause of cancer deaths.

And it’s projected to climb to second place by 2030.

But there’s hope on the horizon. Scientists are zeroing in on a promising strategy…

Liquid biopsy tests could detect the telltale signs of pancreatic cancer in a simple blood sample.

So, what exactly is a liquid biopsy? In a nutshell, it’s a test that looks for cancer markers in bodily fluids— like blood. These markers could be anything from tumor DNA to specific proteins or even tiny vesicles called exosomes that are shed by cancer cells.

The idea is that even when a tumor is too small to cause symptoms or show up on a scan, it’s already leaving clues in the bloodstream.

If we can identify and track those clues, we might be able to catch pancreatic cancer in its earliest, most treatable stages.

One particularly exciting approach comes from researchers at the City of Hope Comprehensive Cancer Center in California. They’ve developed a liquid biopsy test that homes in on microRNAs—tiny snippets of genetic material—found in exosomes in the blood.

In a study of nearly 1,000 people from across the globe, this microRNA test was able to correctly identify 97 percent of stage I and II pancreatic cancers in US participants. That’s a game-changer, because currently, only about 20 percent of pancreatic cancers are caught in those early stages.

The test also had a false positive rate of less than 5 percent, meaning it rarely mistook healthy people for cancer patients—a crucial consideration for any screening tool.

Other research teams are exploring different angles. Some are looking at protein biomarkers in the blood, while others are analyzing bits of tumor DNA that break off and circulate in the bloodstream.

The road to a reliable early detection test is long and winding, but the potential payoff is immense. If we could diagnose pancreatic cancer before it spreads, survival rates could skyrocket.

While the search for an early detection test continues, there are steps you can take today to lower your risk of pancreatic cancer:

  • Don’t smoke. It’s the single biggest risk factor you can control.
  • Maintain a healthy weight through diet and exercise.
  • Limit your alcohol intake.
  • Know your family history. Some genetic syndromes can increase pancreatic cancer risk.

Remember, knowledge is power. Stay informed about the latest research, and don’t hesitate to talk to your doctor if you have concerns.

To putting the brakes on pancreatic cancer,

Rachel Mace
Managing Editorial Director, e-Alert
with contributions from the research team

P.S. Learn more ways to cut your risk of pancreatic cancer, here.

Sources:

https://www.cnn.com/2024/04/08/health/pancreatic-cancer-early-detection-liquid-biopsy-study/index.html

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